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Dedifferentiated liposarcoma

3 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 2

Li-Fraumeni syndrome

3 OMIM references -
2 associated genes
16 signs/symptoms

Dedifferentiated liposarcoma

Li-Fraumeni syndrome

CDK4	(UniProt - OMIM)		CHEK2	(UniProt - OMIM)
HMGA2	(UniProt - OMIM)		TP53	(UniProt - OMIM)
MDM2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MDM2 MDM2	(0.97) (0.88)	TP53 CHEK2

Citations in the biomedical literature:

Dedifferentiated liposarcoma		Li-Fraumeni syndrome
	Synonym(s): - DDLS		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare oncologic disease		Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare neurologic disease - Rare oncologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: adult Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: - Type of inheritance: autosomal dominant

	External references: No OMIM references No MeSH references		External references: 3 OMIM references - 1 MeSH reference: D016864

Li-Fraumeni syndrome
	Very frequent - Acute leukemia - Autosomal dominant inheritance - Bone / osseous neoplasm / tumor / carcinoma / cancer - Breast neoplasm / tumor / carcinoma / cancer - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Colon neoplasm / tumor / carcinoma / cancer - Cortical adrenal neoplasm / tumor / carcinoma / cancer - Lymphoma - Neoplasms / tumors - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Sarcoma - Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma) - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma Occasional - Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Melanoma - Oropharyngeal neoplasm / tumor / carcinoma / cancer
Dedifferentiated liposarcoma
(no data available)